The St. Jude environment facilitates interaction among laboratory scientists and clinical investigators, promoting the translation of new findings from the lab to the clinic and communicating clinical problems to laboratory scientists for further investigation. Our 22 academic departments are home to more than 120 fundamental and translational research labs that bring the ‘bench to the bedside,’ ensuring that patients treated at St. Jude benefit fully from advances in our understanding of pediatric catastrophic diseases and their treatment.